A responsive MRI contrast agent to monitor functional cell status
نویسندگان
چکیده
منابع مشابه
A responsive MRI contrast agent to monitor functional cell status.
It has been shown that insoluble Gd chelates are suitable MRI contrast agents for conditional activation by intracellular lipases. The DTPA-based, insoluble, inactive contrast agent was internalized into dendritic cells by phagocytosis. Cleavage of long aliphatic side chains by intracellular lipase activity leads to the contrast agents solubility and hereby its activation depending on the enzym...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2006
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2006.05.009